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KMID : 0351619720130020255
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Kyungpook Medical Journal
1972 Volume.13 No. 2 p.255 ~ p.263
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Inhibitory Effects of Various Drugs in Experimentally Infected Murine Leprosy
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Abstract
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In order to study inhibitory ?ffects of DDS, Ciba 1~Oo, INHA and SM in experimentally infected murine leprosy, 103 mice were used two mice were used for control 50 mice were inoculated subcutaneously at the right side of the lower abdomen and were designated as the group A, another 50 mice were inoculated mycobacteria subcutaneously at the right side of the back and designated as the group B.
Each group A and B were divided into 5 subgroups for the control, DDS, Ciba 190Ei, INAH and SJI and were adminstered with respective drug to each subgroup.
Groin A was observed by spreading method and group L´ observed by the leprom size. The results were as follows;
A. Rerults of spreading method:
1) The ,nycob:zcteria inoculated were observed in the monocytes and polymorphonuc]ear cells as fin:: masses on the next day of inoculation.
2) In the control group, the mycobacteria in the monocyte on the 2nd week of inoculation were more elongated and increased in number. The: e were much increase in number of money tes and decrease of polymorphonuclear cell;. The above feature vas morf; clearly obser: e1 on the 4th week of inoculation. The prep gyration of the spreading method was impossible because of formation of the leprom.
3) Oniv the IN AH was to seem to be effective on the and and 3rd week ap~l the DDS, Ciba 1996 and SCI show no inhibitory effect, B. Results of the leprom formation:
1) In the control group, on the 4th week 3 mice began to form leprom and on the 6th week it was formed in all of the mice and on the 8th grow to 18th week, it to maximum size. There was ulcer formation in 5 mice.
2) In the DDS group, on the 4th week the leprom was observed only in one mouse on the 6th week the leprom was found in all of them and reached the maximum size, on the 6th to 16th week. The ulcer was observed only in one mouse.
3) In the Ciba 1906, on the 2nd week the leprom was found only in one mouse, and on the 4th week in 7 mice, and on 6th week it was found in all mice, of the group and reached to maximum size on the 16th week.
4) In the INAH group, on the 4th week the leprom was observed in one mouse but it disappeared on the 6th week and appeared again on the 8th to 10th week and disappeared again on the 12th week and reappeared on the 18th week. In one other mouse, small leprom was found on the 14th week and durated to the 18th week, in other 2 mice the leprom was found on the 18th week.
5) In the SM group, on the 6th week leprom was observed in ? mice, and on the 10th week it was found in all mice, and they were grown gradually to maximum size in the 18th. week.
6) In inhibitory effect of INAH against the experimental murine leprosy was the strongest among the drugs tested.
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